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Int J Mol Sci ; 22(4)2021 Feb 09.
Article in English | MEDLINE | ID: covidwho-1082973

ABSTRACT

The purpose of the study was to obtain an external coating based on nanoparticles of ZnO, carvacrol, and geraniol that could be active against viruses such as SARS-Co-V2. Additionally, the synergistic effect of the chosen substances in coatings was analyzed. The goal of the study was to measure the possible antibacterial activity of the coatings obtained. Testing antiviral activity with human pathogen viruses, such as SARS-Co-V2, requires immense safety measures. Bacteriophages such as phi 6 phage represent good surrogates for the study of airborne viruses. The results of the study indicated that the ZC1 and ZG1 coatings containing an increased amount of geraniol or carvacrol and a very small amount of nanoZnO were found to be active against Gram-positive and Gram-negative bacteria. It is also important that a synergistic effect between these active substances was noted. This explains why polyethylene (PE) films covered with the ZC1 or ZG1 coatings (as internal coatings) were found to be the best packaging materials to extend the quality and freshness of food products. The same coatings may be used as the external coatings with antiviral properties. The ZC1 and ZG1 coatings showed moderate activity against the phi 6 phage that has been selected as a surrogate for viruses such as coronaviruses. It can be assumed that coatings ZG1 and ZC1 will also be active against SARS-CoV-2 that is transmitted via respiratory droplets.


Subject(s)
Acyclic Monoterpenes/chemistry , Anti-Bacterial Agents/chemistry , Antiviral Agents/chemistry , Cymenes/chemistry , Metal Nanoparticles/chemistry , Zinc Oxide/chemistry , Anti-Bacterial Agents/pharmacology , Antiviral Agents/pharmacology , Bacteriophages/drug effects , COVID-19/pathology , COVID-19/virology , Drug Carriers/chemistry , Gram-Negative Bacteria/drug effects , Gram-Positive Bacteria , SARS-CoV-2/drug effects , SARS-CoV-2/isolation & purification
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